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系(所)簡介
吳佩芬 副教授

吳佩芬 Wu, Pei-Fen

職稱  副教授

學歷  高雄醫學大學博士

電話  +868-8-7624002 ext. 2127

Email  russell @tajen.edu.tw

學經歷

1.高雄醫學院公共衛生學系學士(1986/9-1990/6)

2.高雄醫學院公共衛生研究所碩士(1990/9-1992/6)

3.高雄醫學大學醫學研究所博士(1998/9-2002/7)

4.大仁藥理專科學校講師(1992/8-1997/12)

5.大仁科技大學副教授(1998/1~迄今)

專長

職業安全衛生法規、職業衛生管理、作業環境監測、工業毒物學、高等統計學、科學研究方法 、

環境與職業流行病學

專業服務經歷

 碩、博士學位口試委員

1. 大仁科技大學

2. 中華醫事科技大學

 國內碩士學位入學考命題委員

1. 大仁科技大學

校內及校外政府各項委外計畫評選委員

1. 大仁科技大學100學年度校務會議代表

2. 大仁科技大學101學年度校教師評審委員

執行計畫

1. 探討樟芝萃取物於細胞缺氧性傷害下調控HIF-1/PI3K /MAPK/VEGF機轉與能量代謝之分析研究
   主持人, 屏東基督教醫院, 2018/01/01~2018/12/31.

2. 探討樟芝萃取物於細胞缺氧性傷害下調控PI3K/AKT/m-TOR/P70S6K/4EBP1蛋白激酶機轉之分析研究
   主持人, 屏東基督教醫院, 2017/01/01~2017/12/31.

3. 探討樟芝萃取物於細胞缺氧性傷害下調控基質金屬蛋白酶與ERK½/JNK/p38k蛋白激酶機轉之分析研究
   主持人, 屏東基督教醫院, 2016/01/01~2016/12/31.

4. 探討樟芝萃取物於細胞缺氧性傷害下調控細胞訊息之分析研究
   主持人, 屏東基督教醫院, 2015/01/01~2015/12/31.

5. 中草藥萃取物之抑制癌細胞研究,
   主持人, 晟杏生物科技, 2014/07/15~ 2015/07/14

6. 山芙蓉萃取物造成攝護腺癌細胞細胞凋亡之研究,
   共同主持人, 屏東基督教醫院, 2015/01/01~2015/12/31

7. 長期照護機構環境與失智症患者行為精神障礙的相關性,
   科技部, 2014/08/01 ~ 2015/07/31, 科技部

8. 環境毒物生化檢測電子訊號化商品開發, 主持人, 金屬中心, 101/06/1-101/11/30.

9. 探討樟芝萃取物抑制大腸癌研究, 共同主持人, 屏東基督教醫院, 101/03/1-102/2/28.

期刊論文

接受及刊登之期刊論文 (Journal papers)

1. Wen-Tsun Lee, Pei-Fen Wu, Tai-An Chiang, Ya-Fang Huang, Tung-Po Chao, Shu-hen Wang. Apoptosis of prostate cancer LNCaP cells induced by Antrodia camphorata extract. Medical Journal of South Taiwan, 2017.13:20-28.

2. Chiang,Ya-Fang Huang, Liang-Lan Hsing, Shiuh-Nan Chang, Pei-Fen Wu*. The apoptosis signal transduction of Antrodia camphorate extracts treatment on hypoxia-stress cells. BioMed Research International (Journal of Biomedicine and Biotechnology). Under revision. [SCI Impact Factor: 2.8:50/160 ].

3. Shu-Chen Wang; Wen-Tsun Lee; Tai-An Chiang; Shiuh-Nan Chan; Ya-Fang Huang; Liang-Lan Hsing; Pei-Fen Wu. The modulation of apoptosis of prostate cancer cell by complex Chinese herbs extract. Journal of Taiwan Medical Laboratory Science. 2016,31(4),10-15.

4. Wen-Tsun Lee #; Tai-An Chiang#; Shiuh-Nan Chan#; Shu-Chen Wang; Ya-Fang Huang; Liang-Lan Hsing; Heng-Teng Lin *; Pei-Fen Wu *. The modulation of apoptosis of breast cancer cell by complex Chinese herbs extract. Bulletin of Taiwan Society of Laboratory Medicine, 2015, 30(4), 25-30. (#co-first author)

5. Shiuh-Nan Chang; Tai-An Chiang; Heng-Teng Lin; Pei-Fen Wu*. The signal transduction pathway of apoptosis by Antrodia camphorate extracts in human liver cancer cell. Bulletin of Chung Hwa University of Medical Technology, 2015, 43,1-12.

6. Tai-An Chiang; Wen-Chuan Chen; Pei-Fen Wu*. The Investigation on Musculoskeletal Disorders of fire-fighters in Taiwan, Pingtung County. Bulletin of Chung Hwa University of Medical Technology, 2015, 42, 15-24.

7. Chuan-Yin Fang, Pei-Fen Wu, Tung-Po Chao, Shiuh-Nan Chang, Ya-Fang Huang, Heng-Teng Lin, Tai-An Chiang*. The signal transduction pathway of apoptosis by Hibiscus Taiwanensis extracts in Human Colon Cancer Cell. Medical Journal of South Taiwan, 2014,10:108-115.

8. Tung-Po Chao, Pei-Fen Wu#, Ya-Fang Huang, Shiuh-Nan Chang, Heng-Teng Lin, Tai-An Chiang, Yin-Chu Lu*. The signal transduction pathway of apoptosis by Antrodia camphorate extracts in Human Colon Cancer Cell. Medical Journal of South Taiwan, 2013, 9, 89-97.

9. Yin-Chu Lu, Pei-Fen Wu, Tai-An Chiang, Shiuh-Nan Chang, Shu-Chen Wang, Hsin-Che Wu, Ya-Fang Huang, Heng-Teng Lin, Tung-Po Chao. The signal transduction pathway of apoptosis by Antrodia camphorate extracts in Human Breast Cancer Cell. Medical Journal of South Taiwan, 2014, 10, 11-29.

10. Tai-An Chiang, Sheng-Fong Wang, Pei-Fen Wu. A Study of the mental pressure among fire-fighters, Pingtung county. Taiwanese Journal of Medical Technologists, 2012, 2(1), 39-49.Heng-Teng Lin. Shu-Chen Wang, Yen-Che Lu, Ya-Fang Huang, Sheng-Dong Shih, Yi-Nan Wu, Ming-Lan Chang, Wen-Tsun Lee, Pei-Fen Wu*, Shiuh-Nan Chang, Tai-An Chiang*, Tung-Po Chao*.  The protect effect of Bromelain on cerebral vascular accident. Taiwanese Journal of Medical Technologists, 2012, 2(1), 33-38. (*corresponding authors with equal contribution)

11. Ya-Fang Huang #, Shu-Chen Wang #,Heng-Teng Lin #, Tsung-Jen Hung4,Chien-Ya Hung 5,Jui-Ming Huang, Jung-   Yien Chien, Shun-Tien Chien, Yi-Nan Wu, Hung-Yao Chang,Wen-Tsun Lee, Tai-An Chiang *, Wei-Zhen Huang    *,Pei-Fen Wu * ,Tung-Po Chao*. The inhibitory effects of Antrodia camphorata extracts on inducing apoptosis in the    lung cancer cells. Taiwanese Journal of Medical Technologists, 2011, 1(2), 19-24.

12. Wu, Pei Fen ; Wu,Yung Hua;Chiang, Tai An. A preliminary study of airborne bio-aerosols in indoor environment of    the hospital, southern Taiwan. Taiwanese Journal of Medical Technologists, 2011, 1(2), 11-18. 

13. Heng-Teng Lin#,    Shu-Chen Wang#, En-Li Chu#, Ya-Fang Huang , Sheng-Dong Shih , Yi-Nan Wu, Pei-Fen Wu*, Tai-An Chiang*, Wen-   Tsun Lee* Analysis of genetic polymorphisms of MDR1 promoter among nervous system tumor patients. Taiwanese   Journal of Medical Technologists, 2011, 1(1), 37-41.

14. Tai-An Chiang, Yu-Lin Yang, Ya-Ying Yang, Min-Shou Hu, Tao-Chen Lee, Pei –Fen Wu, Tung-Nan Liao, Min-Yuan    Hung, Chien-Ya Hung, Tsung-Jen Hung. Hyperosmolarity enhanced susceptibility to renal tubular fibrosis by   modulating Catabolism of Type I Transforming Growth Factor-β Receptors. J Cell Biochem. 2010 Mar 1;109(4):663-   71.

15. Yuan-Wei Shih, Pei-Fen Wu, Yi-Chieh Lee, Ming-Der Shi, Tai-An Chiang. Myricetin Suppresses Invasion and   Migration of Human Lung denocarcinoma A549 Cells: Possible Mediation by Blocking the ERK Signaling Pathway.     J Agr Food Chem. 2009 May 13;57(9):3490-9.

16. Yuan-Wei Shih, Jiunn-Min Shieh, Pei-Fen Wu, Yi-Chieh Lee, Yi-Zhi Chen, Tai-An Chiang. Plumbagin inhibits    invasion and migration of liver cancer HepG2 cells by decreasing productions of matrix metalloproteinase-2 and   urokinase- plasminogen activator. Hepatol Res. 2009;39(10):998-1009.

研討會論文

1. Chuan-Ja Lin, Tai-An Chiang, Shan-Run Chen, Pao-Lung Wang; Shu-Chen Wang, Pei-Fen Wu*. The MAPK signal transduction pathway of growth inhibition by Hylocereus Polyrhizus extracts in Human Prostate Cancer Cell (F059) Asia-Pacific Medical Laboratory Science Forum 2018. Apr 14-15.

2. Ya-Fang Huang, Tai-An Chiang, Liang-Lan Hsing, Chia-Hua Chen, I-Chiao Tsai, Pei-Fen Wu*. Elucidation of the anti-breast cancer role of matrix metalloproteinase by RNA interference (RNAi) under Hibiscus Taiwanensis extracts (F057) Asia-Pacific Medical Laboratory Science Forum 2018. Apr 14-15.

3. Liang-Lan Hsing, Tai-An Chiang, Ya-Fang Huang, Chia-Hua Chen, I-Chiao Tsai, Pei-Fen Wu*. The modulation of signal transduction of PI3K/AKT/mTOR on anti-hypoxia-stress effects by Antrodia camphorate extracts (F058) Asia-Pacific Medical Laboratory Science Forum 2018. Apr 14-15.

4. Yao-Lung Tsai, Tai-An Chiang, Chia-Hua Chen, I-Chiao Tsai, Pei-Fen Wu*. Elucidation of the role of MMPs and ERK JNK p38k under Hibiscus Taiwanensis extracts in the treatment of liver cancer (F002) Asia-Pacific Medical Laboratory Science Forum 2018. Apr 14-15.

5. Ya-Fang Huang, Tai-An Chiang, Pei-Fen Wu, Lin Lin Pan, Chang-Geng Lin. The modulation of signal transduction pathway by green tea polyphenols on colon cancer cells (PO-00) The 33rd World Congress of the International Federation of Biomedical Laboratory Science (IFBLS2018). Sep 22-26 in Florence, Italy.

6. Tai-An Chiang, Chen-Han Hou, Chuan-Ja Lin, Ya-Fang Huang, Pei-Fen Wu*. The signal transduction pathway of apoptosis by bromelain in human prostate cancer cells. (No:C010). Cross-strait Laboratory Medicine Symposium in 2014. (Aug. 23-24).

7. Tai-An Chiang, Chen-Han Hou, Chuan-Ja Lin, Ya-Fang Huang, Pei-Fen Wu*. The growth inhibition of liver cancer cell by gonoderma lucidum specific extracts.  (No:C011). Cross-strait Laboratory Medicine Symposium in 2014. (Aug. 23-24).

8. Tai-An Chiang, Chen-Han Hou, Chuan-Ja Lin, Ya-Fang Huang, Pei-Fen Wu*. T The growth inhibition by green tea polyphenols in human breast cancer cell.  (No:C012). Cross-strait Laboratory Medicine Symposium in 2014. (Aug. 23-24)

9. Tai-An Chiang, Chen-Han Hou, Chuan-Ja Lin, Ya-Fang Huang, Pei-Fen Wu*.The modulation of Erk and p38mapk by phellinus igniarius extracts in human colon cancer cell. (No:C013). Cross-strait Laboratory Medicine Symposium in 2014. (Aug. 23-24)

10. Tai-An Chiang, Chen-Han Hou, Chuan-Ja Lin, Ya-Fang Huang, Pei-Fen Wu*.A study of airborne bacteria concentrations in elder care and rehabilitation centers. (No:E014). Cross-strait Laboratory Medicine Symposium in 2014. (Aug. 23-24)

11. Chen-Han Hou , Tai-An Chiang , Shun-Teien Chien , Wen-Ping Wei , Jui-Ming Huang , Pei-Fen Wu. The synergistic effect of gene polymorphisms on drug induced side-effects among patients with pulmonary tuberculosis (P41). 2014 annual meeting of the Taiwan genomic medicine and biomarker society symposium on clinical application of genomic medicine.

12. Tai-An Chiang, Chuan-Ja Lin, Yin-Chu Lu, Chuan-Yin Fang, Pao-Lung Wang, Pei-Fen Wu*. The Modulation of Apoptosis by Complex Chinese H

13. Pei-Fen Wu, Sheng-Fong Wang, Tai-An Chiang. A Study of the mental pressure among fire-fighters, Pingtung county. (Oral presentation: E001) Asia-Pacific Medical Laboratory Science Forum 2011.

14. Chia-Ling Wu, Ge-Nan Lin, Shwu-Yuann Lin, Pei-Fen Wu, Shu-Chen Wang,  Heng-Teng Lin,  Shu-Chen Wang, Yi-Nan Wu, Sheng-Dong Shih, Ya- Fang Huang, Tai-An Chiang*. The Relationship of Metabolic Syndrome and PPAR-gamma Gene Polymorphism in Chronic Schizophrenic Inpatients.    (No: P176). The Annual Meeting of Taiwan Society of Laboratory Medicine Nov. 5-6, 2011.

15. I-Hsuan Tzeng,  Tai-An Chiang, Pei-Fen Wu,. A preliminary study of airborne bio-aerosols in indoor environment of the hospital, southern Taiwan. (Oral presentation: E003) Asia-Pacific Medical Laboratory Science Forum 2011.

16. Pei-Fen Wu, Yung-Hua Wu, Tai-An Chiang. Evaluation for health hazards of environmental microorganism in the  ambulance among fire-fighters, Pingtung county. (Oral presentation: E003) Asia-Pacific Medical Laboratory Science Forum  2011.

17. Shun-Pin Hsu, Pei-Fen Wu, Chin Hsun Hsu, Tai-An Chiang. The UGT1A7 Gene Polymorphisms Among Lung Cancer Patients. (NO. PA25). 2010  Annual Meeting of Taiwan Society of Pulmonary and Critical Care Medicine Dec. 11-12, 2010.

專書

生物統計學(ISBN:978-986-412-862-4) 作者:李正忠、林泰榮、吳佩芬、張瑞珠、戴秀華、尹順君、王志騰 出版社:高立圖書 出版日期:101年2月。

指導之碩士論文

1.    王招舜”屏東縣國民小學教師校園暴行被害情緒智慧與身心健康之研究”,
大仁科技大學環境管理研究所(104年6月)

2.    陳彥儒”長期照護機構環境因子與失智症患者行為精神障礙的相關性探討”,
大仁科技大學環境管理研究所(103年7月)

3.    陳文川”消防人員肌肉骨骼傷害調查及其相關因素探討-以屏東縣為例”,
大仁科技大學環境管理研究所(103年6月)

4.    吳志男”消防人員創傷症候群與睡眠障礙分析研究-以屏東縣為例”,
大仁科技大學環境管理研究所(103年6月)

5.    張哲豪”消防人員心理壓力與生理指標相關性探討-以屏東縣為例”,
大仁科技大學環境管理研究所(103年6月)

6.    曾智宏”消防人員之噪音暴露及聽力損失情形分析與探討-以屏東縣為例”,
大仁科技大學環境管理研究所(103年6月)

7.    吳永華 ”南部醫療院所室內環境因子與生物氣膠之特性分析”, 大仁科技大學環境管理研究所(101年6月)

8.    王勝豐 “台灣地區職業與十大死因及癌症之年齡年代世代效應分析”,
大仁科技大學環境管理研究所(預定101年6月)

9.    曾宜萱 “救護車之生物性氣膠及消防人員心理壓力評估-以屏東縣為例”,
大仁科技大學環境管理研究所(100年6月)

10.  楊鎧任 “檳榔萃取液暴露雄鼠之睪丸組織GPX家族抗氧化酵素及神經細胞與生殖基因表現之毒性研究”, 大仁科技大學環境管理研究所(99年7月)

專利與技術轉移

A.送審人專利3 件
(1).專利名稱:具發光二極體照明功能之微量吸取器(Micropipette with Led light)
(2).專利名稱:具發光二極體照明功能之充電式吸管輔助器(Portable Pipet-Aid with Led light)
(3).專利名稱:具自動偵測粒徑數量與雲端功能之多階採樣器

B.技術轉移案共6件
(1)技轉主題:乳酸菌提升免疫力功能分析技術
(2)技轉主題:中草藥萃取物之分析技術
(3)技轉主題:UGT基因鑑定分型技術
(4)技轉主題:UGT基因晶片技術
(5)技轉主題:樟芝有效成分劑型化技術
(6)技轉主題:樟芝有效成分鑑定技術 

榮譽及相關證書

1. 2014學年度優良導師

2. 2011年大仁科大藥學既健康學院學術研究成果發表環境管理研究所第一名

3. 2010年亞太醫學檢驗科學國際研討會年度優秀論文獎

4. 2009年亞太醫學檢驗科學國際研討會年度優秀論文獎

5. 2008年亞太醫學檢驗科學國際研討會年度優秀論文獎

6. 下水道設施操作維護─ 水質檢驗乙級技術士證照

7. 有機溶劑作業主管

8. 特定化學物質作業主管

9. 丙級化學技術士證照